melanocytoma of optic disc

Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. These dark brown to black colored tumors are usually located on the optic nerve head, and many a time, the asymptomatic nature [4] of this condition prompts discovery only on routine ophthalmic examination. nerve fiber layer defects). Patients with optic disc melanocytoma should undergo periodic ocular examination. For example, if the tumor is next to the optic nerve, growth can compress the nerve and cause loss of vision (e.g. It is important to differentiate this benign lesion from a malignant melanoma. Fundus photograph of a 49- year-old gentlemen with a characteristic dark brown elevated pigmented mass lesion centered on optic disc and extending into temporal peripapillary area classically suggestive of optic disc melanocytoma. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. It is important to differentiate this benign lesion from a malignant melanoma. They can grow, but rarely transform into a malignancy. melanocytoma of the optic disc, a lesion best known to ophthalmologists, has received considerable attention in the literature. Histopathologically, melanocytoma is composed of deeply . Fluorescein angiography can be useful to differentiate between malignant melanoma and melanocytoma. Contributor Secondary: Valérie Biousse, MD: Publisher [] In majority of instances the tumor remains stable throughout the life and only observation is warranted. [2,3] A 10-year longitudinal study has shown that the tumor size could increase in up to 32% of cases and malignant transformation to melanoma could . Growth can also cause compressive vascular problems . 1 Melanocytoma is described as a benign, small, round, pigmented mass, composed of heavily pigmented oval or round cells with abundant cytoplasm and small nuclei. Contributor Secondary: Valérie Biousse, MD: Publisher Optic disc melanocytoma is typically less than 2 mm raised darkly pigmented mass lesion, which is known to be stationary or show minimal growth [].Melanocytoma classically involves the optic disc and in 18% of the patients it remains confined to the optic nerve head, while 77% cases have retina involvement, and 47% have choroidal involvement [2,3]. Fundus photograph of a 49- year-old gentlemen with a characteristic dark brown elevated pigmented mass lesion centered on optic disc and extending into temporal peripapillary area classically suggestive of optic disc melanocytoma. Melanocytoma of the optic disc is an ophthalmic tumor that arises from melanocytes and is a variant of the melanocytic nevus. The benign nature of optic disc melanocytomas in contrast to th … Histologically the melanocytoma is composed of deeply pigmented round to oval nevus cells with benign cytologic features. Optic disk melanocytoma may be confined to the optic disk or it may have contiguous involvement of the choroid or sensory retina. 2-6 Although melanocytoma can be located anywhere within the uveal tract, it is most commonly found within . We report a case of a 77 year old lady with an Optic nerve head . 1-4 Although the color fundus photo showed a black color, the multicolor image detected the superficial nature of the lesion by showing a greenish hue along with the black color. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue [Skip to Navigation] It occurs more in dark skinned . Optic nerve head melanocytoma (ONM) typically appears as black or dark-brown tumors with feathery or "fuzzy" margins located on the optic disc that often extend into the adjacent retina, choroid and vitreous. Optic disk melanocytoma is an incidental finding and hence the patients are usually asymptomatic. Discover. Optic disc melanocytoma (ODM) is a rare, benign, deeply pigmented ocular tumor arising from melanocytes within the optic disc or from any part of the uvea. Color photographs centered on the optic discs show a normal right optic disc; the left optic disc shows an elevated, dark, pigmented lesion on the superior aspect of the optic disc consistent with an optic disc melanocytoma. It is necessary to differentiate it from other neoplasms such as choroidal melanoma and choroidal nevus. It is probably due to mild compression of the optic disk fibers by the melanocytoma cells, a factor that also explains the associated visual field defect. An optic disc melanocytoma is characteristically a benign lesion [1], with a potential for malignant transformation [2,3]. Melanocytoma is an unusual variant of nevus that classically occurs in the optic nerve head. Optic disk melanocytoma is a benign neoplasm, which seldom exhibits malignant transformation; nevertheless it can show growth and several complications. the presence of a benign melanocytic nevus of the optic disc, termed melanocytoma, was first proposed in 1959 by zimmerman. It is important to differentiate this benign lesion from a malignant melanoma. 1-4 Although the color fundus photo showed a black color, the multicolor image detected the superficial nature of the lesion by showing a greenish hue along with the black color. Also note the pigment dispersion and retinal edema just superotemporal to the lesion secondary to tumor necrosis. It can be confined to the optic disc or have contiguous involvement of the choroid, sensory retina, or vitreous. Optic disc melanocytoma (ODMC) is a rare, benign intraocular tumor that primarily occurs in the optic nerve head and manifests as a melanotic mass. Histologically the melanocytoma is composed of deeply pigmented round to oval nevus cells with benign cytologic features. The benign nature of optic disc melanocytomas in contrast to the urgency needed in optic nerve malignant melanomas makes the differential diagnosis even more critical. 15,20,21,33 It is characteristically a dark brown to black lesion that is located partly in the optic disc. Optic nerve melanocytoma is typically a benign tumor made up of melanocytes and melanin. Melanocytoma of the optic disc is an ophthalmic tumor that arises from melanocytes and is a variant of the melanocytic nevus. Melanocytoma of the optic disk: a review Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. Today, howe … It is important to differentiate this benign lesion from a malignant melanoma. Symptoms Optic nerve melanocytoma does not usually produce symptoms or grow. However, local growth can harm adjacent tissues. Rarely it exhibits minor enlargement and can also undergo malignant transformation to a melanoma. Histologically the melanocytoma is composed of deeply pigmented round to oval nevus cells with benign cytologic features. Optic disk melanocytoma is a benign neoplasm, which seldom exhibits malignant transformation; nevertheless it can show growth and several complications. Abstract Melanocytoma of the Optic nerve head, is a benign, stationary pigmented tumor present on or adjacent to the optic disc. Optic disc melanocytoma is a benign lesion of the optic nerve head that poses little threat to vision and carries low malignancy potential. The involvement of the adjacent retina was observed better on the multicolor . Histopathologically a melanocytoma consists of intensely pigmented round to oval nevus cells with benign features. On rare occasions, it may lead to severe vision loss ( 1,2 ). The term "melanocytoma" was first used in 1962 by Zimmermann to describe a benign, asymptomatic hamartomatous tumor that arises from melanocytes [1]. Seen clinically and confirmed on AF imaging, the tumor occupied 3-tissue spaces - limited within the optic disc only (n = 2), extended into retinal layer (n = 5) and extended into retina-choroidal layers (n = 4). Conclusion: Optic disc melanocytoma can present with visual impairment and a floater. It needs to be differentiated from the other lesions of the optic disc in view of the grossly varied treatment and prognosis of these conditions. Optic disk melanocytoma is one of the few conditions in which this paradoxical pupillary reaction can occur. Histopathologically a melanocytoma consists of intensely pigmented round to oval nevus cells with benign features. Swept-source optical coherence tomography angiography (OCT-A) is a relatively new device . Melanocytoma of the Optic nerve head, is a benign, stationary pigmented tumor present on or adjacent to the optic disc. Color photographs centered on the optic discs show a normal right optic disc; the left optic disc shows an elevated, dark, pigmented lesion on the superior aspect of the optic disc consistent with an optic disc melanocytoma. 1 ONM was first reported in 1907 by Coats, who suspected melanocytomas were benign tumors. (a) Conventional color fundus image of the left eye showing an elevated, brownish-black mass measuring approximately 1.5 × 1.5 DD in size over the optic nerve head and extending into the adjacent retina inferiorly (black arrow). This pigmented lesion occurs on the optic disc and often extends into the peripapillary retina and choroid. Today, howe … Color fundus image and multicolor imaging demonstrating the optic disc melanocytoma. 1 Although melanocytoma was believed to be benign, 1 there are rare reports of transformation into malignant melanoma, heralded by tumor growth or decrease in vision. It is relatively small and confined to the disc in 15% ( Fig. We report two cases of melanocytoma of the optic disc that show that visual function can be significantly affected. Also note the pigment dispersion and retinal edema just superotemporal to the lesion secondary to tumor necrosis. 2-6 although melanocytoma can be located anywhere within the … 2-5 A study of 115 patients revealed malignant . It generally does not affect vision, although a small proportion of patients may experience minor visual impairment as the tumor expands. The presence of a benign melanocytic nevus of the optic disc, termed melanocytoma, was first proposed in 1959 by Zimmerman. Ophthalmoscopically, optic nerve melanocytoma has typical features. We report two cases of melanocytoma of the optic disc that show that visual function can be significantly affected. There was no subretinal fluid (SRF) surrounding the tumor in any eye. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. It can be confined to the optic disc or have contiguous involvement of the choroid, sensory retina, or vitreous. More characteristically, it extends over the margin of the optic disc to involve the adjacent . Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. Optic disc melanocytoma is a deeply pigmented variant of benign melanocytic nevus that has been confused with malignant melanoma. There was associated optic disc edema in 2 eyes. Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. Optic nerve head melanocytoma (ONH-MCT) is a benign dark brown to black pigmented lesion located either within or adjacent to the optic disc. Before the 1960s, melanocytoma of the optic disc was thought to be a malignant neoplasm. The common perception that melanocytomas of the optic disc do not affect visual function is one that must be challenged. 1 Though afferent pupillary defect and visual field defects are sometimes reported, 4 spontaneous necrosis of the tumor or compressive optic neuropathy can result in severe visual loss in rare instances. If they slowly grow, optic nerve melanocytoma can produce afferent pupillary defects (30%), subretinal fluid (10%), and an enlarged blind spot (75%). Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. 135.1 ). Rarely it exhibits minor enlargement and can also undergo malignant transformation to a melanoma. It is necessary to differentiate it from other neoplasms such as choroidal melanoma and choroidal nevus. Before the 1960s, melanocytoma of the optic disc was thought to be a malignant neoplasm. Conclusions: Although melanocytoma of the optic disc generally is considered to be a benign, stationary lesion, it can produce several local complications, can cause visual loss, can grow slowly, and, rarely, can undergo malignant transformation into melanoma. It is important to differentiate this benign lesion from a malignant melanoma. Optic disk melanocytoma may be confined to the optic disk or it may have contiguous involvement of the choroid or sensory retina. Although melanocytoma was beli Our website uses cookies to enhance your experience. 20,34-38 most statistical information on optic disc melanocytoma … Melanocytoma is a deeply pigmented variant of melanocytic nevus that classically occurs in the optic disk, sometimes with contiguous involvement of the adjacent retina or choroid. 1 melanocytoma is described as a benign, small, round, pigmented mass, composed of heavily pigmented oval or round cells with abundant cytoplasm and small nuclei. This pigmented lesion occurs on the optic disc and often extends into the peripapillary retina and choroid. Optic disc melanocytoma is a benign lesion of the optic nerve head that poses little threat to vision and carries low malignancy potential. Melanocytoma is an unusual variant of nevus that classically occurs in the optic nerve head. Optic disk melanocytoma may be confined to the optic disk or it may have contiguous involvement of the choroid or sensory retina. Historically, this tumor was often confused with malignant melanoma both clinically and histopathologically. 1 We report a case, which presented with . E. Discussion. Optic disc melanocytoma is a deeply pigmented variant of benign melanocytic nevus that has been confused with malignant melanoma. 1-38 since the last edition of this textbook, there have been only a few noteworthy publications in the english language literature related to this tumor.

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